摘要/Abstract
摘要： 稀土元素也称镧系元素,因其独特的发光性质和配位性质,其发光复合物被广泛研究于生物技术领域。其中稀土铽（III）离子复合物因具有优异的光谱特性,关于其研究呈现出快速的发展趋势。主要从其发光特性的角度出发,探讨了其发光机理,并对铽（III）离子与不同有机化合物结合形成的发光铽配合物以及铽（III）离子及其配合物与不同纳米材料形成的复合物进行了分类综述。此外,还详细地阐述了铽离子及其复合物在荧光探针、生物传感器、药物递送、细胞成像、癌症治疗等相关领域的应用。最后,对其今后发展趋势和潜在的研究价值进行了展望。
关键词:
铽（III）离子,
铽（III）离子配合物,
发光,
荧光探针,
生物传感器,
细胞成像
Abstract: Rare earth elements,also known as Lanthanide elements,their luminescent compounds have been widely used in the field of biotechnology due to their unique luminescent properties and coordination properties. Among them,research on the rare earth terbium（III）complexes shows a rapid tendency due to their excellent spectral properties. From the perspective of luminescent properties of terbium（III）complexes,this article discusses their luminescence mechanism. Subsequently,this article classifies and reviews the luminescent terbium（III）complexes via the binding of terbium（III）ions with different organic compounds and even with different nanomaterials. In addition,this article expatiates the applications of terbium（III）complexes in fluorescent probes,biosensors,drug delivery,cell imaging,cancer treatment and other related fields in detailed. Finally,this article prospects their future development trend and potential value.
Key words:
terbium（III）ions,
terbium（III）complex,
luminescence,
fluorescent probe,
biosensors,
cell imaging
引用本文
柳苏月, 田晶晶, 田洪涛, 许文涛. 铽（III）离子及其复合物：从发光特性到传感应用[J]. 生物技术通报, 2020, 36(4): 192-207.
LIU Su-yue, TIAN Jing-jing, TIAN Hong-tao, XU Wen-tao. Terbium（III）and Its Complexes：from Luminescent Properties to Sensing and Bioimaging Applications[J]. Biotechnology Bulletin, 2020, 36(4): 192-207.
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https://biotech.aiijournal.com/CN/10.13560/j.cnki.biotech.bull.1985.2019-0604
https://biotech.aiijournal.com/CN/Y2020/V36/I4/192
参考文献
[1] Weissman SI.Intramolecular energy transfer the fluorescence of complexes of europium[J]. The Journal of Chemical Physics, 1942, 10(4):214-217.[2] Hildebrandt N, Wegner KD, Algar WR.Luminescent terbium complexes:Superior Förster resonance energy transfer donors for flexible and sensitive multiplexed biosensing[J]. Coordination Chemistry Reviews, 2014, 273:125-138.[3] Wu JX, Yan B.Luminescent hybrid Tb3+ functionalized metal-organic frameworks act as food preservative sensor and water scavenger for NO2-[J]. Industrial & Engineering Chemistry Research, 2018, 57(21):7105-7111.[4] Tan H, et al.Luminescence detection of cysteine based on Ag+-mediated conformational change of terbium ion-promoted G-quadruplex[J]. Analytica Chimica Acta, 2016, 908:161-167.[5] Jastrząb R, Nowak M, Skrobańska M, et al.DNA as a target for lanthanide(III)complexes influence[J]. Coordination Chemistry Reviews, 2019, 382:145-159.[6] Ju R, Gu Q.Biohybrid based on layered terbium hydroxide and applications as drug carrier and biological fluorescence probe[J]. Applied Organometallic Chemistry, 2018, 32(1):e3926.[7] Chen Y, Ma F, Chen X, et al.A new bis(phthalocyaninato)terbium single-ion magnet with an overall excellent magnetic performance[J]. Inorg Chem, 2017, 56(22):13889-13896.[8] Zhu Q, et al.Grafting of terbium(iii)complexes onto layered rare-earth hydroxide nanosheets to fabricate novel optical fiber temperature sensors[J]. Nanoscale, 2019, 11(6):2795-2804.[9] Fu PKL, Turro C.Energy transfer from nucleic acids to Tb(III):selective emission enhancement by single DNA mismatches[J]. Journal of the American Chemical Society, 1999, 121(1):1-7.[10] Kleinke K, et al.Label-free Ag+ detection by enhancing DNA sensitized Tb3+ luminescence[J]. Sensors, 2016, 16(9):1370.[11] Xu L, Zhou W, Liu J.Enhanced DNA sensitized Tb3+ luminescence in organic solvents for more sensitive detection[J]. Analytica Chimica Acta, 2017, 977:44-51.[12] Gómez-Hens A, Aguilar-Caballos MP.Terbium-sensitized luminescence:a selective and versatile analytical approach[J]. TrAC Trends in Analytical Chemistry, 2002, 21(2):131-141.[13] Khorasani-Motlagh M, Noroozifar M, Niroomand S, et al.Photoluminescence studies of a Terbium(III)complex as a fluorescent probe for DNA detection[J]. Journal of Luminescence, 2013, 143:56-62.[14] Chi BZ, Liang RP, Yuan YH, et al.Luminescence determination of microRNAs based on the use of terbium(III)sensitized with an enzyme-activated guanine-rich nucleotide[J]. Microchimica Acta, 2018, 185(5):280.[15] Georges J.Lanthanide-sensitized luminescence and applications to the determination of organic analytes. A review[J]. Analyst, 1993, 118(12):1481-1486.[16] Zhou W, Saran R, Liu J.Metal sensing by DNA[J]. Chemical Reviews, 2017, 117(12):8272-8325.[17] Xue SF, Chen ZH, Han XY, et al.DNA encountering Terbium(III):A smart “chemical nose/tongue” for large-scale time-gated luminescent and lifetime-based sensing[J]. Anal Chem, 2018, 90(5):3443-3451.[18] Aulsebrook ML, Starck M, Grace MR, et al.Interaction of nucleoti-des with a trinuclear terbium(III)-dizinc(II)complex:effici-ent sensitization of terbium luminescence by guanosine monophos-phate and application to real-time monitoring of phosphodiesterase activity[J]. Inorganic Chemistry, 2018, 58(1):495-505.[19] Chen BB, Liu ML, et al.Terbium(III)modified fluorescent carbon dots for highly selective and sensitive ratiometry of stringent[J]. Analytical Chemistry, 2018, 90(6):4003-4009.[20] Jiang H, Zhang X, Wang G.[G3T]5/Tb3+ based DNA biosensor with target DNA-triggered autocatalytic multi-cycle-amplification and magnetic nanoparticles assisted-background-lowered[J]. Biosensors and Bioelectronics, 2015, 74:931-938.[21] Zhang M, et al.DNA-based sensitization of Tb3+ luminescence regulated by Ag+ and cysteine:use as a logic gate and a H2 O2 sensor[J]. Chemical Communications, 2014, 50(36):4677-4679.[22] Zhang M, Le HN, Jiang XQ, et al.Time-resolved probes based on guanine/thymine-rich DNA-sensitized luminescence of terbium(III)[J]. Analytical Chemistry, 2013, 85(23):11665-11674.[23] Sen D, Gilbert W.A sodium-potassium switch in the formation of four-stranded G4-DNA[J]. Nature, 1990, 344(6265):410.[24] Liu L, Zhang C, Yu Y, et al.Determination of DNA based on fluorescence quenching of terbium doped carbon dots[J]. Microchimica Acta, 2018, 185(11):514.[25] Akiba H, et al.Click conjugation of a binuclear terbium(III)complex for real-time detection of tyrosine phosphorylation[J]. Analytical Chemistry, 2015, 87(7):3834-3840.[26] Yang Y, et al.Lanthanide doped coordination polymers with tunable afterglow based on phosphorescence energy transfer[J]. Chemical Communications, 2017, 53(55):7752-7755.[27] Gao R, et al.Ordered and flexible lanthanide complex thin films showing up-conversion and color-tunable luminescence[J]. Journal of Materials Chemistry C, 2014, 2(45):9579-9586.[28] Wang W, Yang J, et al.Luminescent terbium-organic framework exhibiting selective sensing of nitroaromatic compounds(NACs)[J]. Crystal Growth & Design, 2015, 15(6):2589-2592.[29] Wang X, Li JL, Jiang C, et al.An efficient strategy for improving the luminescent sensing performance of a terbium(iii)metal-organic framework towards multiple substances[J]. Chemical Communications, 2018, 54(94):13271-13274.[30] Qi Z, Chen Y.Charge-transfer-based terbium MOF nanoparticles as fluorescent pH sensor for extreme acidity[J]. Biosensors and Bioelectronics, 2017, 87:236-241.[31] Ye Z, et al.Preparation, characterization, and time-resolved fluoro-metric application of silica-coated terbium(III)fluorescent nano-particles[J]. Analytical Chemistry, 2004, 76(3):513-518.[32] Chen Y, Chi Y, Wen H, et al.Sensitized luminescent terbium nanoparticles:preparation and time-resolved fluorescence assay for DNA[J]. Analytical Chemistry, 2007, 79(3):960-965.[33] Yu A, et al.Establishment of a new analytical platform for glucose detection based on a terbium containing silica hybrid nanosensor[J]. Applied Surface Science, 2018, 462:883-889.[34] Evangelista RA, Pollak A, Templeton EFG.Enzyme-amplified lanthanide luminescence for enzyme detection in bioanalytical assays[J]. Analytical Biochemistry, 1991, 197(1):213-224.[35] Hemmilá I, et al.Time-resolution in fluorometry technologies, labels, and applications in bioanalytical assays[J]. Critical Reviews in Clinical Laboratory Sciences, 2001, 38(6):441-519.[36] Azab HA, Khairy GM, El-Ghany NA, et al.Time-resolved fluorescence sensing of N-acetyl amino acids, nucleobases, nucleotides and DNA by the luminescent Tb(III)-8-alkyl-2-oxo-2H-chromene-3-carbaldehyde probe[J]. Journal of Luminescence, 2016, 176:181-192.[37] Degorce F, Card A, Soh S, et al.HTRF:a technology tailored for drug discovery-a review of theoretical aspects and recent applications[J]. Current Chemical Genomics, 2009, 3:22.[38] Qiu X, Wegner KD, et al.Nanobodies and antibodies for duplexed EGFR/HER2 immunoassays using terbium-to-quantum dot FRET[J]. Chemistry of Materials, 2016, 28(22):8256-8267.[39] Ivnitski D, Abdel-Hamid I, Atanasov P, et al.Biosensors for detection of pathogenic bacteria[J]. Biosensors and Bioelectronics, 1999, 14(7):599-624.[40] Wu T, Fang B, Chang L, et al.Sensitive determination of DNA based on the interaction between prulifloxacin-terbium(III)complex and DNA[J]. Luminescence, 2013, 28(6):894-899.[41] Soltani N, Manzoori JL, Amjadi M, et al.Development and validation of a spectrofluorimetric determination of calf thymus DNA using a terbium-danofloxacin probe[J]. Pharmaceutical Sciences, 2016, 22(1):2.[42] Zhang J, Wu D, Chen QX, et al.Label-free microRNA detection based on terbium and duplex-specific nuclease assisted target recycling[J]. Analyst, 2015, 140(15):5082-5089.[43] Chen Q, Zuo J, Chen J, et al.A label-free fluorescent biosensor for ultratrace detection of terbium(ш)based on structural conversion of G-quadruplex DNA mediated by ThT and terbium(ш)[J]. Biosensors and Bioelectronics, 2015, 72:326-331.[44] Pal S, Bharadwaj PK.A luminescent terbium MOF containing hydroxyl groups exhibits selective sensing of nitroaromatic compounds and Fe(III)ions[J]. Crystal Growth & Design, 2016, 16(10):5852-5858.[45] Pazos E, Torrecilla D, Vázquez López M, et al. Cyclin A probes by means of intermolecular sensitization of terbium-chelating peptides[J]. Journal of the American Chemical Society, 2008, 130(30):9652-9653.[46] Han Y, Li H, Hu Y, et al.Time-resolved luminescence biosensor for continuous activity detection of protein acetylation-related enzymes based on DNA-sensitized terbium(III)probes[J]. Analytical Chemistry, 2015, 87(18):9179-9185.[47] Xu M, Gao Z, Zhou Q, et al.Terbium ion-coordinated carbon dots for fluorescent aptasensing of adenosine 5'-triphosphate with unmodified gold nanoparticles[J]. Biosensors and Bioelectronics, 2016, 86:978-984.[48] Powell JF.Isolation of dipicolinic acid(pyridine-2:6-dicarboxylic acid)from spores of Bacillus megatherium[J]. Biochemical Journal, 1953, 54(2):210.[49] Luo Y, Zhang L, Zhang L, et al.Multiporous terbium phosphonate coordination polymer microspheres as fluorescent probes for trace anthrax biomarker detection[J]. ACS Applied Materials & Interfaces, 2019, 11(17):15998-16005.[50] Rosen DL, Sharpless C, McGown LB. Bacterial spore detection and determination by use of terbium dipicolinate photoluminescence[J]. Analytical Chemistry, 1997, 69(6):1082-1085.[51] Wang QX, Xue SF, Chen ZH, et al.Dual lanthanide-doped complexes:the development of a time-resolved ratiometric fluorescent probe for anthrax biomarker and a paper-based visual sensor[J]. Biosensors and Bioelectronics, 2017, 94:388-393.[52] Wabaidur SM, Alothman ZA, et al.Sensitive determination of dopa-mine by its fluorescence enhancement on terbium(III)-dipicolinic acid system[J]. Sensor Letters, 2012, 10(1-2):92-95.[53] Steinkamp T, Karst U.Detection scheme for bioassays based on 2, 6-pyridinedicarboxylic acid derivatives and enzyme-amplified lanthanide luminescence[J]. Analytica Chimica Acta, 2004, 526(1):27-34.[54] Tang G, Zhao C, Gao J, et al.Colorimetric detection of hydrogen sulfide based on terbium-G-quadruplex-hemin DNAzyme[J]. Sensors and Actuators B:Chemical, 2016, 237:795-801.[55] 贾永梅, 娄筱叮, 夏帆. 核酸荧光探针在单细胞成像中的应用研究[J]. 分析化学, 2018, 46(9):1329-1338.[56] Law GL, Wong KL, Man CWY, et al.Emissive terbium probe for multiphoton in vitro cell imaging[J]. Journal of the American Chemical Society, 2008, 130(12):3714-3715.[57] Zhou Z, et al.Molecular imaging of biothiols and in vitro diagnostics based on an organic chromophore bearing a terbium hybrid probe[J]. Dalton Transactions, 2016, 45(17):7435-7442.[58] Bui AT, Grichine A, Duperray A, et al.Terbium(III)luminescent complexes as millisecond-scale viscosity probes for lifetime imaging[J]. Journal of the American Chemical Society, 2017, 139(23):7693-7696.[59] Dasari S, Singh S, Sivakumar S, et al.Dual-sensitized luminescent europium(III)and terbium(III)complexes as bioimaging and light-responsive therapeutic agents[J]. Chem Eur J, 2016, 22:17387-17396.
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